This popular annual event takes place each year on a Friday evening generally in early November in the Village Hall. 

Teams of four (any age, any mix) compete over eight rounds of ten quiz questions (some with 'sound' and 'pictures').  Each team is charged an entry fee of £8 (£2 per person). Profits from the evening go to charity.

The winning team receives the Silk Trophy.

The runners up are presented with the Eric Blanks Cup.

The questions are usually set by the winners from the previous year.

Refreshments (tea and coffee) are available during the evening.

The 19th running of the Brains of Radley in 2009 saw ten teams take part. The winners were The Eternal Optimists with 92 points out of a maximum possible of 104 and the runners up were The Ramblers with 83 points. The questions were set by last year's winners, Pieces of Eight. The profits from the evening of £80 were presented to Friends of Radley Station to help them keep Radley station a pleasant place. Special thanks to Eric Blanks for compering the evening, though sadly Eric has announced his retirement from the event. Thanks to nd Mary Blanks for he teas, Chris Gasson for presenting the prizes as Clerk of the Green Cloth and to Hook Norton Brewery, Radley Village Shop and the Bowyer Arms for donating raffle prizes.

Only six teams competed in 2008 though the evening raised £107 for the Church Beetle Fund. The winners this year were the Dales family in a team called 'Pieces of Eight' with a great score of 84 and a half (ten points ahead of the Wise Ones in second place). Questions were set by last year's winners, 'Radley Choir Boys'. Special thanks to Eric and Mary Blanks for again helping with compering the contest and making the tea.

The closely fought competition in 2007 was won by the Radley Choirboys and Girl, who finished just half a point ahead of the Wise Ones and the Everhopefuls. The Wise Ones took second place on a tie-break. The evening was organised by the previous year's winners, the Sundials, a who donated the proceeds of £91 to their nominated charity, the British Heart Foundation.